ABSTRACT
Aims and objective :To compare combinations of Propofol-Ketamine and Propofol-Fentanyl for total intravenous anesthesia in short surgical cases in pediatric patients. The study also compared recovery characteristics and the incidence of side effects / complications in the groups. Methodology: The patients were randomly divided into two groups depending upon the drug combination used for Total Intravenous Anaesthesia. Group I : 30 patients were given i.v. Ketamine followed by Propofol. Group II: 30 patients were given i.v. Fentanyl followed by Propofol Recovery characteristics were compared and the incidence of side effects and complications in two groups were noted. Results: The pulse rate and blood pressure remained near to preinduction value in group I, while in group II these values decreased. After induction RR increased in group I but decreased in group II at 1,3%5 min after induction.None of the patients in both groups were observed to have nausea, vomiting and respiratory depression. . A significant no. of the patients in group II were observed to have either pain on injection site or restlessness. Conclusion: Propofol-Ketamine and Propofol-Fentanyl combinations provide satisfactory surgical conditions for minor surgical procedures in paediatric patients, but the Propofol-Ketamine combination gives better hemodynamic stability and less restlessness during induction and maintenance of anaesthesia.